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2353 пппппп п402 Inhibitory postsynaptic potential, 253, 258, 259, 261 Inositol (1,4,5) trisphosphate (IP3) formation, 121, 122, 127 Insulin secretion, 357 Intracellular ionic concentrations, 215 Intrinsic activity, 182, 187, 190, 191 Iodophenpropit, 196 [125I]Iodophenpropit, 196, 197, 200 - as first H3 radioligand antagonist, 196 - binding affinity, 197 - biphasic displacement, 197, 198 [125I]Iodoproxyfan, 198 Ion channels, 215-224 - as membrane proteins, 217 - as target for drugs, 215, 217 - binding sites, 215, 217 - classification, 217 - function, 215, 216 - general properties, 215-217 - ligand and voltage-gated, 215, 217 - modulated receptor concept, 223 - opening and closing, 215, 217 - regulatory sensors, 217 - selective drugs, 218 - states, 223 - structure, 216, 217 KВ channel - ATP-sensitive (KATP), 227 - charybdotoxin-sensitive, 232 - large conductance, CaВ (BKCa), 232 - openers, 227 KВ channel activators (KCAs), 227-239 - airways-selective, 232, 233 - ATP-dependent, 217 - bladder-selective, 233-235 - cardioprotective, 231 - in CNS disorders, 235,236 - structure series, 229, 230 Kainate, 241,245,247-249 Kainate receptors, 243, 244, 245, 249 - molecular biology, 244 - preferring states, 249 Kappa opioid agonists, 291,292, 297 - as analgesic drugs, 291 - binding model, 297 - conformational requirement, 294 - non-peptides, 291,292 - pharmacophore model, 297, 298 - selective, 294, Binary options zero risk strategy avoiding divorce books for children - structure, 296 Kappa opioid analgesics, SAR, 291-300 Kappa receptor, 291,292, 297 Kappa selective ligands, 293,297, 300 KC-128, 232 KC-399, 229, 231 Kidney, 356 L-364,718 (Devazepide), 376, 377, 384 L-365,260, 377, 384 Lead generation and selection, 5 Lead structures, 4 Learning and memory processes, 53 Learning improving effects, 255 Levcromakalim - blood pressure lowering, 232 - clinical profile, 227, 228 - inhibition of seizures, 236 Page 99 EUROPEAN PHARMACOPOEIA 7.

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